The Secretariat, headed by the Secretary General / CEO, is responsible for implementing the policies and directives laid down by the Council.
| Name / Designation | Appointed on |
| Mr Benjamin J William Secretary General & CEO |
1 March 2012 |
| Ms Eileen Cher Assistant Secretary General, Corporate |
16 January 2023 |
| Ms Charis Chan Assistant Secretary General, Operations |
|
| Mr Prakash Menon Srikumaran Group Director, Blood Donor Programme |
|
| Mr Sahari Ani Group Director & Dean, Singapore Red Cross Academy |
|
| Mr Adrian Lim Director, Care Services |
1 January 2020 |
| Ms Iris Choong Director, Corporate Management |
1 January 2019 |
| Mr Isaac Tiong Director, Finance Management |
|
| Ms Rebekah Lim Associate Director, Global Engagement |
1 April 2024 |
| Ms Karine Tan Associate Director, Community Engagement |
1 July 2024 |
| Ms Agnes Ting Head, Blood Donor Programme |
20 December 2022 |
| Mr Rick Lee Head, Blood Donor Programme |
1 December 2022 |
| Mr Ambrose Lee Head, Centre for First Aid and Life Support |
1 April 2022 |
| Ms Durga Naidu Muthusamy Head, Centre for Psychosocial Support |
1 July 2024 |
| Ms Jaime Ong Head, Marketing & Communications |
2 October 2023 |
| Mr Johnny Tang Head, Resource Development |
1 April 2020 |
| Mr July de Leon Head, Volunteer Management |
1 April 2022 |
| Ms Rubavathi Manickam Head, Youth Development |
16 August 2024 |
